RAF Typhoon FGR4s have operated alongside France's air force in a coordinated attack on an hidden munitions depot in Syrian territory used by the IS group, per a report from the UK Ministry of Defence.
The site, pinpointed through reconnaissance, was believed to be housing weapons and explosive materials, the announcement noted, and was located in mountainous terrain just above Palmyra in central Syria.
"The RAF jets used Paveway IV guided bombs to strike a several approach shafts leading to the depot... early reports suggest the objective was successfully hit," officials stated.
There was no indication of any harm to civilians in the strike on Saturday evening and each participating jet made a safe return, the MoD added.
The Typhoon FGR4s were supported by a Voyager tanker plane.
The Islamic State group - alternatively referred to as ISIS - enforced extremist governance over large swathes of Iraq and Syria prior to its 2019 collapse.
"This operation demonstrates our UK leadership, and determination to stand shoulder to shoulder with allied nations, to eliminate any re-emergence of the terrorist group and their harmful and extremist ideologies in the region," UK Defence Secretary the Defence Secretary stated.
RAF aircraft have conducted overwatch operations over Syria to "prevent any efforts to regroup" of Islamic State following its routing at the Baghuz confrontation in the year 2019, the authorities noted.
"I want to thank all the members of British forces who took part in this operation for their expertise and their courage," the Defence Secretary added. "They were among a great many British personnel on duty over the festive period. This mission, to take out terrorist threats who endanger our safety, highlights how our armed forces are prepared to act, continuously, ensuring Britain's security domestically and powerful internationally."
In December, the United States armed forces conducted what it described as a "large-scale strike" against IS targets in the country, following an assault killed two US servicemembers and a civilian linguist in Palmyra.
The U.N. estimates Daesh still has an estimated 5,000 to 7,000 fighters in Iraq and Syria.